Roberto de Oliveira M. Mitochondrial Intoxication 2023

Textbook in PDF format

Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included.This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.
Mitochondrial physiology: An overview
Molecular markers of mitochondrial intoxication
Drug-induced mitochondrial impairment: Mechanisms and testing systems
Challenges in mitochondrial profiling during pre-clinical studies
Mitochondrial dysfunction and underlying molecular mechanisms in acrylamide-induced toxicity
The effects of air pollution toxicants on the mitochondria
Mitochondrial toxicity of aflatoxin B1
The effects of the alcohol abuse against the mitochondria. Functional consequences for liver, muscle, and the brain
The effect of aluminum on mitochondrial dysfunctions
Discovery of amiodarone mitochondrial toxicity in liver and beyond
Ammonia
The mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines
Mitochondrial intoxication by anthracyclines
Antidepressants, mood stabilizing drugs and mitochondrial function; for better or for worse
The effects of antiretroviral drugs on the mitochondria
The effect of arsenical compounds on mitochondrial metabolism
Mechanisms of bisphenol A toxicity in mitochondria
Chemotherapeutic drugs
Effects of cuprizone on mitochondria
Effects of Δ9-tetrahydrocannabinol on mitochondria
Effects of food additives on the mitochondria integrity and functioning
Mitochondria as a toxicological target for fungicides
The effects of methylglyoxal on the mitochondria
The effect of mercury on the mitochondria
Organohalogens
The effects of organophosphate pesticides on the mitochondria
Mitochondrial oxygen toxicity
Polychlorinated biphenyls
The effects of polycyclic aromatic hydrocarbons on mitochondria
The effects of pyrethroids on the mitochondria
The effects of sodium nitrate on mitochondria
Mitochondrial zinc toxicity